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Millipore Anti-Hgitr Antibody, Clone 108-17 Is A Highly Specific Mouse Monoclonal Antibody & That Targets Gitr & Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Tumor necrosis factor receptor superfamily member 18
Activation-inducible TNFR family receptor
Glucocorticoid-induced TNFR-related protein
CD357
Background Information
Glucocorticoid-induced TNFR-related protein (hGITR) is also called Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), Activation-inducible TNFR family receptor (AITR) and CD357. hGITR is a receptor for TNFSF18 and is activated by NF-kappa-B through the TRAF2/NIK pathway. hGITR is thought to be involved in activated T-lymphocyte and endothelial cell interactions, as well as regulation of T-cell receptor-mediated cell death. hGITR is expressed in lymph node, peripheral blood leukocytes and at low levels in the spleen.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-hGITR Antibody, clone 108-17 is a highly specific mouse monoclonal antibody & that targets GITR & has been tested in western blotting.
Key Applications
Western Blotting
Application Notes
Western Blotting Analysis: 1.0 µg/mL from a representative lot detected hGITR in 10 µg of mouse lymph node, rat spleen, and rat thymus tissue lysate.
Biological Information
Immunogen
Recombinant protein corresponding to human hGITR.
Clone
108-17
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Mouse
Rat
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_004186
Gene Symbol
TNFRSF18
AITR
GITR
UNQ319/PRO364
Purification Method
Protein A Purfied
UniProt Number
Q9Y5U5
Molecular Weight
~ 26 kDa observed. Multiple bands can be observed due to GITR being a monomer & homeodimer in some lysates. Uncharacterized band(s) may appear in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected hGITR in 10 µg of human spleen tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
