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Millipore This Rat Monoclonal Anti-Cd11b Antibody, (Human/Mouse), Redfluor™ 710, Clone M1/70, Cat. No. Mabf804 Is Validated For Use In Flow Cytometry, For The Detection Of Cd11b. - Mill (Additional S&H or Hazmat Fees May Apply)
The M1/70 antibody reacts with human and mouse CD11b, also known as integrin alpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin receptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrins are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin receptors consist of distinct combinations of integrin chains which are differentially expressed. Integrin alpha M (CD11b) assembles with Integrin beta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.The M1/70 antibody is widely used as a marker for CD11b expression on mouse macrophages, granulocytes, neutrophils, and NK cells. The antibody is also reported to be cross-reactive for Rhesus macaque CD11b.
Product Information
Format
redFluor™ 710
Presentation
Purified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality Level
MQ100
Applications
Application
This rat monoclonal Anti-CD11b Antibody, (human/mouse), redFluor™ 710, clone M1/70, Cat. No. MABF804 is validated for use in Flow Cytometry, for the detection of CD11b.
Key Applications
Flow Cytometry
Biological Information
Immunogen
Immunogen information for this antibody is proprietary information.
Clone
M1/70
Concentration
Please refer to lot specific datasheet.
Host
Rat
Isotype
IgG2bκ
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Gene Symbol
Itgam
Purification Method
Purified by size-exclusion chromatography
UniProt Number
P05555
Product Usage Statements
Quality Assurance
This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Flow Cytometry Analysis: 0.25 μg from a representative lot detected CD11b in one million C57Bl/6 bone marrow cells.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions
Stable for 1 year at 2-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
