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Millipore Detect Bdca-2 Using This Anti-Bdca-2 Antibody, Clone 10e6.1 Validated For Use In Western Blotting & Ihc. - Mill (Additional S&H or Hazmat Fees May Apply)
Blood dendritic cell antigen 2 (BDCA-2;CD303) is a type II C-type lectin that is expressed on plasmacytoid dendritic cells (PDC), a subset of immature dendritic cells found in lymphoid and nonlymphoid tissues. BDCA-2 is critically involved in both adaptive and innate immune responses. It is involved in the recognition and internalization of pathogens, but inhibits TLR6 signaling and INF-1 production, in PDC cells, possibly through signaling of the BCR-like signalosome. PDC signaling has been linked to multiple inflammatory diseases such as granulomatous lymphadenitis.
Product Information
Format
Purified
Control
Recombinant BDCA-2 protein
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mm NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Detect BDCA-2 using this Anti-BDCA-2 Antibody, clone 10E6.1 validated for use in Western Blotting & IHC.
Key Applications
Western Blotting
Immunohistochemistry
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected BDCA-2 in human tonsil tissue.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human BDCA-2.
Clone
10E6.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_569708
Gene Symbol
CLEC4C
BDCA2
CLECSF11
CLECSF7
DLEC
HECL
Purification Method
Protein g Purified
UniProt Number
Q8WTT0
Molecular Weight
~33 kDa observed. Uncharacterized bands appear at ~25 and ~31 kDa in some lysates.
Product Usage Statements
Quality Assurance
Evaluated by Western Blot in recombinant BDCA-2 protein.
Western Blot Analysis: 1 µg/mL of this antibody detected BDCA-2 on 10 µg of recombinant BDCA-2 protein.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
