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Millipore Anti-Abca4 Antibody, Clone 5d7.1 | Mabn287 Is An Antibody Against Abca4 Antibody For Use In Western Blotting, Immunohistochemistry (Paraffin). - Mill (Additional S&H or Hazmat Fees May Apply)
Retinal-specific ATP-binding cassette transporter encoded by the gene ABCA4 plays a critical role in the transport of retinoid substrates from the extracellular or intradiscal rod cell membranes to the cytoplasmic membrane surface for processing ultimately into vitamin A and then transferred to the retinal pigment epithelium where it is converted to 11-cis-retinal that active component needed for vision. ABCA4 is localized to the outer segments of rods and cones with a million copies per photoreceptor. ABCA4 is retinal specific protein. Mutations in ABCA4 are linked to several eye-related genetic diseases, such as forms of macular degeneration called Stargardt disease and ARMD2, as well as Retinitis pigmentosa 19, and Cone-rod dystrophy 3.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-ABCA4 Antibody, clone 5D7.1 | MABN287 is an antibody against ABCA4 Antibody for use in Western Blotting, Immunohistochemistry (Paraffin).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected ABCA4 in human retina tissue.
Biological Information
Immunogen
Recombinant protein corresponding to human ABCA4.
Clone
5D7.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_000341
Gene Symbol
ABCA4
ABCR
Purification Method
Protein G Purified
UniProt Number
P78363
Molecular Weight
~275 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in Y79 cell lysate.
Western Blotting Analysis: 5.0 µg/mL of this antibody detected ABCA4 in 200 µg of Y79 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
