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Key Specifications Table
| Species Reactivity | Key Applications | Host | Format | Antibody Type |
|---|---|---|---|---|
| H, M | IH(P), WB | M | Purified | Monoclonal Antibody |
| Description | |
|---|---|
| Catalogue Number | MABN352 |
| Description | Anti-delta-type Opioid Receptor, clone 4E6.2 Antibody |
| Alternate Names |
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| Background Information | Delta-type Opioid Receptor (D-OR-1), also known as DOR-1, and encoded by the gene name OPRD1/ OPRD, is a G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Binding of Delta-type Opioid Receptor with ligands causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Delta-type Opioid Receptor signaling has been shown to lead to the inhibition of adenylate cyclase activity. Recent studies have also demonstrated that Delta-type Opioid Receptor inhibits the neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Delta-type Opioid Receptor also may play a role in the perception of pain and in opiate-mediated analgesia. Additionally, it may play a role in developing analgesic tolerance to morphine, and it may form homooligomers. Delta-type Opioid Receptor interacts with GPRASP1. Delta-type Opioid Receptor is detected in oocytes (at protein level), and in brain cortex, hypothalamus, hippocampus and olfactory bulb. |
| Product Information | |
|---|---|
| Format | Purified |
| Presentation | Purified mouse monoclonal IgG2bκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application | This Anti-delta-type Opioid Receptor antibody is validated for use in WB, IH(P) for the detection of delta-type Opioid Receptor. |
| Key Applications |
|
| Application Notes | Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected delta-type Opioid Receptor in human cerebral cortex, human uterus, and human thalamus tissue. |
| Biological Information | |
|---|---|
| Immunogen | GST-tagged recombinant protein corresponding to the C-terminus of human delta-type Opioid Receptor. |
| Epitope | C-terminus |
| Clone | 4E6.2 |
| Concentration | Please refer to lot specific datasheet. |
| Host | Mouse |
| Isotype | IgG2bκ |
| Species Reactivity |
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| Antibody Type | Monoclonal Antibody |
| Entrez Gene Number |
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| Gene Symbol |
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| Purification Method | Protein G Purified |
| UniProt Number |
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| Molecular Weight | ~65 kDa observed. The calculated molecular weight of this protein is 40 kDa, but can be observed at ~65 kDa due to high glycosylation. |
| Product Usage Statements | |
|---|---|
| Quality Assurance | Evaluated by Western Blotting in mouse brain tissue lysate. Western Blotting Analysis: 1.0 µg/mL of this antibody detected delta-type Opioid Receptor in 10 µg of mouse brain tissue lysate. |
| Usage Statement |
|
| Storage and Shipping Information | |
|---|---|
| Storage Conditions | Stable for 1 year at 2-8°C from date of receipt. |
| Packaging Information | |
|---|---|
| Material Size | 100 µg |