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Millipore Anti-Stam-Binding Protein Antibody, Clone 4d12.2
Millipore Anti-Stam-Binding Protein Antibody, Clone 4d12.2
List Price$412.92Your Price$412.92
Millipore This Anti-Stam-Binding Protein Antibody, Clone 4d12.2 Is Validated For Use In Western Blotting And Immunocytochemistry For The Detection Of Stam-Binding Protein. - Mill (Additional S&H or Hazmat Fees May Apply)
STAM-binding protein (STAMBP) is a critical metalloprotease in ubiquitin-mediated signaling events that specifically cleaves Lys-63-linked polyubiquitin chains but does not cleave Lys-48-linked polyubiquitin chains. STAM-binding protein is a deubiquitinating (DUB) isopeptidase also known as AMSH, for associated molecule with the SH3 domain of STAM. STAM-binding protein plays a role in cell growth and MYC induction, potentiates BMP signaling and is key in regulating the cell surface receptor-mediated endocytosis and ubiquitin-dependent sorting of receptors to lysosomes. STAM-binding protein interacts with other key proteins including STAM1, SMAD6/7, SMURF2, and CHMP3. STAM-binding protein is widely expressed and can be found localized to the nucleus, cytoplasm and endosome. Defects in STAM-binding protein result in a congenital syndrome named Microcephaly-capillary malformation syndrome.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ supernatant in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ300
Applications
Application
This Anti-STAM-binding protein Antibody, clone 4D12.2 is validated for use in Western Blotting and Immunocytochemistry for the detection of STAM-binding protein.
Key Applications
Western Blotting
Immunocytochemistry
Application Notes
Immunocytochemistry analysis: 1:50 dilution from a representative lot detected STAM binding protein in A431 cells DyLight™ is a trademark of Thermo Fisher Scientific, Inc. and its subsidiaries.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to Human STAM-binding protein.
Clone
4D12.2
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_006454
Gene Symbol
AMSH
STAMBP
Purification Method
Protein G Purified
UniProt Number
O95630
Molecular Weight
~50 kDa observed
Product Usage Statements
Quality Assurance
Routinely evaluated by western blotting on Jurkat cell lysate Western Blotting Analysis: 1 µg/mL of this antibody detected STAM binding protein in 10 µg of Jurkat cell lysate
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
