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Millipore Anti-Fgf23 Antibody, Clone 278-2 Is A Mouse Monoclonal Antibody & Validated For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Fibroblast growth factor 23 (FGF-23) is also called Phosphatonin and Tumor-derived hypophosphatemia-inducing factor. FGF-23 belongs to the heparin-binding growth factors family and has several important functions including: regulation of phosphate homeostasis, inhibition of renal tubular phosphate transport, upregulation of EGR1 expression, regulation of vitamin-D metabolism, and negative regulation of osteoblast differentiation and matrix mineralization. FGF-23 is expressed in osteogenic cells, adult trabecular bone, osteocytes and flattened bone-lining cells (inactive osteoblasts). Defects in FGF23 can lead to autosomal dominant hypophosphataemic rickets (ADHR) and hyperphosphatemic familial tumoral calcinosis (HFTC).
Product Information
Format
Purified
Control
Human salivary gland tissue lysate
Presentation
Purified mouse monoclonal IgG1κ in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-FGF23 Antibody, clone 278-2 is a mouse monoclonal antibody & validated for use in western blotting.
Key Applications
Western Blotting
Flow Cytometry
Application Notes
Flow Cytometry Analysis: 2 µg from a representative lot detected FGF23 in Jurkat and human PMBC cells.
Biological Information
Immunogen
Corresponding to human FGF23.
Clone
278-2
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_065689
Gene Symbol
FGF23
HYPF
Purification Method
Protein A Purfied
UniProt Number
Q9GZV9
Molecular Weight
~25 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human salivary gland tissue lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected FGF23 in 10 µg of human salivary gland tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
