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Breast cancer anti-estrogen resistance protein 3 (BCAR3), also known as Novel SH2-containing protein 2 (NSP2) and SH2 domain-containing protein 3B (SH2D3B) is an adapter protein that regulates the proliferation in breast cancer cells. BCAR3 may also be regulated by cellular adhesion to extracellular matrix proteins. BCAR3 is found in several cancer cell lines; however, it is not found in nonmalignant breast tissue. When BCAR3 is overexpressed, it confers anti-estrogen resistance in breast cancer cell lines.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-BCAR3, clone 9D9.1 is an antibody against BCAR3 for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human BCAR3.
Clone
9D9.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001248337
Gene Symbol
BCAR3
NSP2
SH2D3B
UNQ271/PRO308
Purification Method
Protein G Purified
UniProt Number
O75815
Molecular Weight
~93 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in U2OS cell lysate.
Western Blotting Analysis: 0.5 µg/mL of this antibody detected BCAR3 in 10 µg of U2OS cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
