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Millipore Anti-Titin (N-Terminal/Z-Domain) Antibody, Clone 17d11.1 Is An Antibody Against Titin (N-Terminal/Z-Domain) For Use In Western Blotting, Ihc(P). - Mill (Additional S&H or Hazmat Fees May Apply)
Titin is a large complex protein containing over one hundred IgG-like and fibronectin type-III domains, in addition to multiple Kelch, RCC1, TPR, and WD repeats. It is a member of the CAMK Ser/Thr protein kinase family and also possesses a protein kinase domain, which is involved in controlling gene expression and protein turnover in muscle tissues. Titin also functions as a sensor to mediate appropriate cellular responses to mechanical stress. In striated muscle tissue, titin regulates the length of the sarcomere by integrating myosin and actin filaments at the Z-disk and M-band, and facilitates the elasticity of the sarcomere. Titin also regulates sarcomere assembly and functions as central hub in signal transduction pathways. Defects in Titin may contribute to various forms of cardiomyopathy.
Product Information
Format
Purified
Control
Human and mouse cardiac muscle tissues
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-Titin (N-terminal/Z-domain) Antibody, clone 17D11.1 is an antibody against Titin (N-terminal/Z-domain) for use in Western Blotting, IHC(P).
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Titin.
Clone
17D11.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Mouse
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_596870
Gene Symbol
TTN
Purification Method
Protein G Purified
UniProt Number
Q8WZ42
Molecular Weight
38 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human and mouse cardiac muscle tissues.
Immunohistochemistry Analysis: 1:1,000 dilution of this antibody detected Titin in human and mouse cardiac muscle tissues.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
