Miltenyi Biotec Cd120b (Tnf-Rii) Antibody, Anti-Mouse, Apc, Reafinity; 30 µg in 200 µL

Miltenyi Biotec Clone REA228 recognizes the extracellular part of the membrane-bound and truncated soluble form of the mouse CD120b antigen, a 75 kD type I transmembrane protein, which is also known as Tumor Necrosis Factor Receptor Type II (TNF-RII). CD120b is a receptor with high affinity for the mouse cytokine TNF-a and with lower affinity for LT-a. It belongs to the TNF receptor superfamily and is largely confined to cells of the immune system. CD120b is strongly expressed on stimulated T and B lymphocytes and on a variety of cells at low levels. Sustained activation of TNF signaling has been implicated in the pathogenesis of a wide spectrum of diseases, including cancer, osteoporosis, sepsis, diabetes, and autoimmune diseases such as multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. Additional information: Clone REA228 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)