Miltenyi Biotec Cd42b Antibody, Anti-Human, PE, Reafinity; 30 Tests in 60 mL

Miltenyi Biotec Clone REA185 recognizes CD42b, a 145 kDa single-pass type I membrane protein. Expression of CD42b is found on platelets and megakaryocytes. CD42b, the a chain, together with the B chain (CD42c), forms the heterodimer, glycoprotein Ib (GP Ib). The GP Ib receptor complex further includes association of the a and B subunits with platelet glycoprotein IX and glycoprotein V and this complex serves as the receptor for von Willebrand factor (VWF). The interaction of the GP Ib-IX-V complex to VWF initiates initial platelet adhesion to vascular subendothelium after vascular injury, platelet activation, thrombosis, and hemostasis. Other known ligands for GPIb–IX–V include a-thrombin, clotting factors XI/XIIa, and high-molecularweight kininogen. | Additional information: Clone REA185 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)