Miltenyi Biotec Tcr Vγ9 Antibody, Anti-Human, Fitc, Reafinity; 30 Tests in 60 mL

Miltenyi Biotec Clone REA470 recognizes the human variable gamma 9 subunit of the γ/ T cell receptor (TCR Vγ9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The γ and TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. Γ T cells represent unconventional lymphocytes that share characteristics of natural killer (NK) cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of γ T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. Γ T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vγ9/V 2 T cells comprise the majority of peripheral human γ T cells and are capable of responding to the microbial metabolite HMB-PP. | Additional information: Clone REA470 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)