Miltenyi Biotec Foxp3 Antibody, Anti-Human, PE, Reafinity; 30 Tests in 60 mL

Miltenyi Biotec Clone REA1253 recognizes the FoxP3 antigen, the forkhead/winged-helix transcriptional regulator FoxP3, also known as forkhead box P3, scurfin, and JM2. FoxP3 is expressed predominantly in regulatory T cells (Tregs) and is a major marker and functional regulator of Treg cell development and function. Mutations in the FoxP3 gene are linked to the autoimmune manifestations observed in the Scurfy mouse and humans with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome. Studies in mice have shown that FoxP3-deficient animals lack Treg cells, whereas overexpression of the FoxP3 protein leads to profound immune suppression. | Additional information: Clone REA1253 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)