Miltenyi Biotec Cd352 (Ntb-A) Antibody, Anti-Human, Fitc, Reafinity; 30 Tests in 60 mL

Miltenyi Biotec Clone REA339 recognizes the human CD352 antigen, a 60 kDa single-pass type I membrane protein also known as SLAM family member 6 (SLAM6) or natural killer (NK), T, and B cell–antigen (NTB-A). CD352 belongs to the CD2 subfamily of the immunoglobulin superfamily and is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. Monoclonal antibody-mediated cross-linking of CD352 results in the induction of NK-mediated cytotoxicity. CD352 also triggers cytolytic activity only in NK cells expressing high surface densities of natural cytotoxicity receptors. This suggests that CD352 may function as a coreceptor in the process of NK cell activation. Importantly, analysis of NK cells derived from patients with X-linked lymphoproliferative disease showed that the lack of SH2D1A protein profoundly affects the function of CD352. | Additional information: Clone REA339 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)