Miltenyi Biotec P53 Antibody, Anti-Human, Fitc, Reafinity; 30 Tests in 60 mL

Miltenyi Biotec Clone REA609 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cells exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. | Additional information: Clone REA609 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)