Miltenyi Biotec Cd170 (Siglec-5) Antibody, Anti-Human, Pure, Reafinity; 100 µg in 100 µL

Miltenyi Biotec Clone REA1077 recognizes the CD170 antigen, a single-pass transmembrane protein member of the immunoglobulin superfamily, also known as sialic acid-binding Ig-like lectin 5 (Siglec-5). CD170 is expressed on neutrophils, monocytes, dendritic cells, and subsets of tissue macrophages. It contains two tyrosine-based motifs in its cytoplasmic tail implicating signaling functions and forms a 140 kDa dimer on the cell surface. Tyrosine phosphorylation of CD170 leads to recruitment of the tyrosine phosphatases SHP-1 and SHP-2, which in turn efficiently inhibits FcεRI-mediated calcium fluxing and serotonin release. CD170 binds a 2-3- and a 2-6-linked sialic acid as well as glycophorin A, and is involved in cell adhesion. | Additional information: Clone REA1077 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)