Miltenyi Biotec Cd79b Antibody, Anti-Human, PE-Vio 770, Reafinity; 100 Tests in 200 µL

Miltenyi Biotec Clone REA120 detects the extracellular epitope of CD79b, the B chain of heterodimeric molecule CD79. CD79 is composed of an a chain (CD79a) and a B chain (CD79b) and is associated with surface immunoglobulins (Igs) to form the B cell receptor (BCR). CD79b is 37–39 kDa type I integral membrane protein and like CD79a contains an intracellular immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Patients with chronic lymphocytic leukemia (CLL) B cells lack a functional BCR which is often associated with mutations in CD79b coding region. | Additional information: Clone REA120 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)