Miltenyi Biotec Cd87 Antibody, Anti-Mouse, Apc, Reafinity; 30 µg in 200 µL

Miltenyi Biotec Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. UPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells. | Additional information: Clone REA630 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)