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L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
Product Information
Format
Purified
Control
Mouse Brain Lysate.
Presentation
Purified in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% NaN3.
Quality Level
MQ100
Applications
Application
This Anti-mGluR4 Antibody is validated for use in WB for the detection of mGluR4.
Key Applications
Western Blotting
Biological Information
Immunogen
Recombinant Protein.
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Rabbit
Specificity
Cat. # AB15097 recognizes mGluR4 (GRM4).
Species Reactivity
Mouse
Rat
Species Reactivity Note
Mouse and Rat. Reactivity with other species has not been determined.
Antibody Type
Polyclonal Antibody
Entrez Gene Number
NP_001013403.1
Gene Symbol
GPRC1D
MGLUR4
mGlu4
mGluR4
Purification Method
Antigen Affinity Purified
UniProt Number
Q68EF4
UniProt Summary
FUNCTION: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity By similarity. SUBUNIT STRUCTURE: Interacts with PICK1 By similarity. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SEQUENCE SIMILARITIES: Belongs to the G-protein coupled receptor 3 family.
Molecular Weight
~101 kDa
Product Usage Statements
Quality Assurance
Western Blot: Mouse Brain Lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
