Cell Signaling Rhodopsin (D4b9b) Rabbit mAb

Name: Cell Signaling Rhodopsin (D4b9b) Rabbit mAb
SKU: CSIG-27182S
Price: 420.16 USD

List Price $420.16 Your Price $420.16

Cell Signaling Rhodopsin (D4b9b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-27182S

MFG.PART: 27182S

UNSPSC: 12352200

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:1000, Immunofluorescence (Frozen): 1:400}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Rhodopsin (D4B9B) Rabbit mAb recognizes endogenous levels of total rhodopsin protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu194 of human rhodopsin protein.
Background	Rhodopsin is the photoreceptor in the retinal rods. It is activated by photons, transduces visual information through its cognate g protein, transducin, and is inactivated by arrestin binding (1). Using atomic-force microscopy, rhodopsin was found to be arranged into paracrystalline arrays of dimers in mouse disc membranes (2). Rhodopsin is considered to be the prototype of g protein-coupled receptors (GPCRs), and is the first GPCR for which a crystal structure was solved (3). Research studies have linked mutations in the gene encoding rhodopsin to retinitis pigmentosa (4,5), a disease characterized by retinal degeneration resulting in reduced peripheral vision and night blindness (6).

Specifications