Cayman Citrullinated Gfap (Human, Recombinant); Purity- Greater T

Citrullinated glial fibrillary acidic protein (citGFAP) is a citrullinated form of GFAP (Item No. ), a class III intermediate filament (IF) protein that is expressed in mature astrocytes and contributes to cytoskeletal structure and strength. GFAP can be citrullinated in a calcium-dependent manner on the arginine residue at position 270 (R270) and at R416 by protein arginine deiminase 1 (PAD1; Item No. ) and PAD2 (Item No. ). citGFAP levels are increased by the calcium ionophore ionomycin (Item No. ) in an in vitro model of traumatic brain injury (TBI) using NHA CC-2565 human astrocytes and are induced by controlled cortical impact in the cerebral cortex in a rat model of TBI. It has been found in the hippocampus in a rat model of Alzheimers disease induced by amyloid-β (25-35), as well as in the retina in a mouse model of alkali-induced eye injury.^, citGFAP has also been found in postmortem hippocampus from patients with Alzheimers disease, and citGFAP levels are increased in postmortem-derived brain lesions from patients with multiple sclerosis.^, Caymans Citrullinated GFAP protein can be used for Western blot and ELISA applications.

WARNING This product is not for human or veterinary use.