Cell Signaling Npl4 Antibody

Name: Cell Signaling Npl4 Antibody
SKU: CSIG-13489S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Npl4 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13489S

MFG.PART: 13489S

UNSPSC: 12352202

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	68, 71
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	NPL4 Antibody recognizes endogenous levels of total NPL4 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys322 of human NPL4 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Nuclear protein localization protein 4 (NPL4, NPLOC4) was originally identified as a yeast nuclear transport protein that was later recognized as a critical component of the endoplasmic reticulum-associated degradation (ERAD) pathway (1,2). Mammalian NPL4 protein has an amino-terminal ubiquitin-like domain containing a p97 binding site, and a conserved carboxy-terminal zinc finger (NZF) motif responsible for binding ubiquitinated target proteins (2,3). NPL4 binds ubiquitin fusion degradation protein 1 (UFD1) to form a heterodimer that associates with the p97 AAA-ATPase, creating a protein complex that mediates delivery of ubiquitinated ER proteins to the proteasome (4,5).

Specifications