We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
GenScript Dnam-1/Cd226 Fc Chimera, Human; 1mg
List Price $1,200.00 Your Price $1,200.00
GenScript Dnam-1/Cd226 Fc Chimera, Human - GSCRPT (Additional S&H or Hazmat Fees May Apply)
NETA PART: GSCRPT-Z03454-1
MFG.PART: Z03454-1
UNSPSC: 12352202
Manufacturer: GenScript USA Inc
Product Introduction
| Species | Human | ||||
| Protein Construction |
| ||||
| Purity | > 95% as analyzed by SDS-PAGE | ||||
| Endotoxin Level | < 1 EU/μg of protein by gel clotting method | ||||
| Biological Activity | Immobilized Rhesus macaque CD155/PVR Protein, His Tag at 1.0 μg/ml (100 μl/well) can bind DNAM-1/CD226, hFc, Human with an EC50 of 0.871 μg/ml when detected by Mouse Anti-Human IgG Fc-HRP. | ||||
| Expression System | HEK 293 | ||||
| Apparent Molecular Weight | ~81.7 kDa, on SDS-PAGE under reducing conditions. | ||||
| Formulation | Lyophilized from a 0.2 μm filtered solution in PBS. | ||||
| Reconstitution | It is recommended that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute the lyophilized powder in ddH₂O or PBS up to 100 μg/ml. | ||||
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | DNAM-1 (DNAX accessory molecule-1), also known as CD226, platelet and T cell activation antigen 1 (PTA1) and TLiSA1, is a member of the Ig superfamily containing two Ig-like domains of the V set and is encoded by a gene on human chromosome 18q22.3. DNAM-1 is an activating receptor expressed on natural killer (NK) cells, CD8+ T cells, and other immune cells. Upon recognition of its ligands, CD155 and CD112, DNAM-1 promotes NK cell–mediated elimination of transformed and virus-infected cells. It also has a key role in expansion and maintenance of virus-specific memory NK cells. DNAM-1 is the cell surface receptor of NECTIN2. Upon ligand binding, it stimulates T cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13 and IFNG. |
| Synonyms | DNAM-1; CD226; PTA1; TLiSA1 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03454-1 |
|---|---|
| Supplier Part Number | Z03454-1 |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | GenScript USA Inc |
| Temperature | Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (examp |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 7 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |