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GenScript Fgf-9, Mouse; 10 μg
List Price $2,595.00 Your Price $2,595.00
GenScript Fgf-9, Mouse - GSCRPT (Additional S&H or Hazmat Fees May Apply)
NETA PART: GSCRPT-Z03575-1
MFG.PART: Z03575-1
UNSPSC: 12352202
Manufacturer: GenScript USA Inc
Product Introduction
| Species | Mouse | ||||
| Protein Construction |
| ||||
| Purity | > 95% as analyzed by SDS-PAGE | ||||
| Endotoxin Level | < 1 EU/μg of protein by LAL method | ||||
| Biological Activity | Measured in a cell proliferation assay using Balb/3T3 mouse embryonic fibroblast cells. The ED50 for this effect is 4.14 ng/ml. | ||||
| Expression System | E. coli | ||||
| Apparent Molecular Weight | ~25 kDa, on SDS-PAGE under reducing conditions. | ||||
| Formulation | Supplied as a 0.2 μm filtered solution in 20 mM Tris, 150 mM NaCl, 5% Trehalose, 1 mM EDTA, 20% glycerol, 1 mM DTT, pH 8.5. | ||||
| Concentration | Please refer to the COA for the specific lot. | ||||
| Storage & Stability | Upon receiving, this product remains stable for up to 6 months at -70°C or below, the product can be stored for 2-3 weeks at 2-8°C or 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
Background
| Target Background | Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo, the location and timing of FGF-9 expression affect the development of the skeleton, cerebellum, lungs, heart, vasculature, digestive tract, and testes. It may have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors. Deletion of mouse FGF-9 is lethal at birth due to lung hypoplasia, and causes rhizomelia, or shortening of the proximal skeleton. An unusual constitutive dimerization of FGF 9 buries receptor interaction sites which lower its activity and increases heparin affinity which inhibits diffusion. A spontaneous mouse mutant, Eks, interferes with dimerization, resulting in monomeric, diffusible FGF-9 that causes elbow and knee synostoses (joint fusions) due to FGF-9 misexpression in developing joints. |
| Synonyms | Fibroblast growth factor 9; Glia-activating factor; GAF; heparin-binding growth factor-9; HBGF-9; Fgf9; Fgf-9 |
For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.
| SKU | GSCRPT-Z03575-1 |
|---|---|
| Supplier Part Number | Z03575-1 |
| UM | EA |
| UNSPSC | 12352202 |
| Manufacturer | GenScript USA Inc |
| Temperature | Upon receiving, this product remains stable for up to 6 months at -70°C or below, the product can be stored for 2-3 weeks at 2-8°C or 3 months at -20°C. Avoid repeated freeze-thaw cycles. |
| ProductLine | GSCRPT |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 7 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |