Revvity HTRF Hman Total ALK Detection Kit, 500 Aay Point

Revvity ALK (analatic lymhoma kinae) i a tranmemrane tyroine kinae elonging to the erfamily of inlin recetor. ALK reglate everal athway involved in cell rvival, roliferation, and cell cycling, inclding the AKTPI3K,MAPKERK, STAT3 and NFkB athway.The ALK ligand, leiotrohin (PTN) and midkine(MDK), indce ALK hohorylation and activation on mltile Tyroine inclding Y1604. ALK dereglation i aociated with vario cancer ch a NSCLC, and nerolatoma. Indeed, oncogenic ALK i driven y i) gene tranlocation and eqent intracelllar ALK fion rotein (eg, EML4-ALK, NPM1-ALK, TPM3-ALK, VCL-ALK); ii) mtation (eg G263, R401, R551, P968 and E1242). Oncogenic ALK i contittively active which relt in ncontroled activation of downtream ignaling athway, leading to tmor cell rvival and roliferation.-PEGSK(Additional S&H Or Hazmat Fees May Apply)