Revvity HTRF Hman Androgen Recetor Fll Length Detection Kit, 500 Aay Point

Revvity The HTRF Hman Fll Length Androgen Recetor detection aay monitor Wild-Tye Androgen Recetor (AR-WT) i.e. fll length (AR-FL). It i ed to detect the exreion of endogeno or overexreed AR-FL within vario cell.The Androgen Recetor i a nclear recetor that i activated y androgen hormone, inclding tetoterone (T) and Dihydrotetoterone (DHT).Androgen ind to the ligand inding domain of the Androgen Recetor, relting in recetor homodimerization and tranlocation to the ncle. Downtream gene exreion and ignaling athway are then activated, inclding the PI3KAKT athway. The gene exreion indced y the Androgen Recetor romote cell diviion, roliferation, differentiation, aotoi, and angiogenei. Dyreglation of the Androgen Recetor athway can lead to oncogenic henotye, with Androgen Recetor activation or exreion having een linked to condition ch a rotate cancer, reat cancer, gliolatoma, and other malignancie. Moreover, Androgen Recetor variant are exreed in vario hman cancer cell line. The develoment of PROTAC comond that target the degradation of the Androgen Recetor i a olar theraetic trategy for targeting Androgen Recetor-oitive cancer.-PEGSK(Additional S&H Or Hazmat Fees May Apply)