Revvity HTRF Human and Mouse Total ATG16L1 Detection Kit, 500 Assay Points

Autophagy Related 16 Like 1 (ATG16L1) is a protein that is essential for autophagy. ATG16L1 is recruited to the phagophore and recruits ATG5-ATG12 complex to a phagophore, facilitating LC3 lipidation (LC3-I to LC3-II conversion) and contributing to autophagosome maturation.

Phosphorylated ATG16L1 at Ser278 is only present on newly-forming autophagosomes, making its quantification an ideal surrogate for autophagic vesicle formation and autophagy induction. ATG16L1 is involved in conditions such as Alzheimers Disease, colorectal cancer, heart disease, breast cancer, and chronic myeloid leukemia.