Revvity HTRF Human and Mouse Total CDK8 Detection Kit, 10,000 Assay Points

CDK8 and its paralog, CDK19, also named "Mediator Kinase" are cyclin-dependent kinases that have been implicated in cellular homeostasis and developmental programming. CDK8 and CDK19 are incorporated, in a mutually exclusive manner, as part of a 4-protein complex called the Mediator kinase module. This module reversibly associates with the Mediator, a 26 subunit protein complex that regulates RNA Polymerase II mediated gene expression. CDK8 has been implicated in the development of different human diseases, and in particular cancer.