Revvity HTRF Hman Total IDO1 Detection Kit, 10,000 Aay Point

Revvity The Total IDO1 cell-aed aay rovide a convenient and accrate way of detecting Total IDO1 level within cell.IDO1 (Indoleamine 2,3 dioxygenae 1) i the mot imortant rate-limiting enzyme of the kynrenine athway de to it aility to catalyze the degradation of L-Trytohan (Tr) to "kynrenine" metaolite (Kyn). Tr deletion and Kyn rodction romote immnoreion y inhiiting CD8+ T effector cell and NK cell. It alo increae the activity of CD4+ Treg cell and MDSC (myeloid-derived reor cell). IDO1 alo lay a key role in romoting new lood veel develoment (angiogenei).IDO1 i overexreed in different tmor cell and infiltrate immne cell, leading to tmor immne ecae and neovaclarization.Althogh IDO1 inhiitor have een develoed to inhiit trytohan metaolim, thee theraie have had limited cce in rolonging atient rvival. Recent effort have hifted to TPD (targeted rotein degradation) of IDO1 a a otentially more efficacio theraetic trategy.-PEGSK(Additional S&H Or Hazmat Fees May Apply)