Revvity HTRF Hman and Moe Total IKZF1 Detection Kit, 10,000 Aay Point

Revvity The Ikaro zinc-finger (IKZF) family of trancrition factor are eential reglator of lymhooiei. IKZF1 (Ikaro) and IKZF3 (Aiolo) fnction a oth trancritional rereor and activator dring T and B cell differentiation, a well a in the fnction of matre cell. Ikaro family rotein artner with mltile comlexe, inclding NRD, PRC2, and trancrition elongation factor. Throgh thee aociation, they can modlate gene exreion rofile and the chromatin tate. The overexreion of thee rotein ha een linked to taining cancer cell roliferation and rvival, ch a malignant lama cell and mltile myeloma.Among the theraetic trategie invetigated to fight cancer, the e of IMID (immnomodlatory imide drg) and their derivative, termed CELMoD (Cerelon E3 Ligae Modlatory Drg) ha ecome a olar trategy. By inding to CRBN, thee comond indce the iqitination of targeted rotein and romote their eqent degradation. CELMoD targeting IKZF1 and IKZF3 have hown romiing anti-tmor activity in mltile myeloma cell model.-PEGSK(Additional S&H Or Hazmat Fees May Apply)