Revvity HTRF Hman Phoho-VAV1 (Tyr174) Detection Kit, 500 Aay Point

Revvity VAV1, alo known a Vav roto-oncogene 1, i a rotein that lay a crcial role in celllar ignaling and immne reone. It i rimarily exreed in cell of hematooietic origin, inclding T cell, B cell, and natral killer cell.VAV1 act a a ganine ncleotide exchange factor (GEF) for the Rho family GTPae, inclding Rac1, Rac2, and RhoA. VAV1 activate thee GTPae y romoting the exchange of GDP (ganoine dihohate) for GTP (ganoine trihohate) on thee enzyme. Throgh thi mechanim, VAV1 i an imortant reglator of eential celllar rocee ch a cytokeletal rearrangement, cell adheion, roliferation, and migration.In immne cell, VAV1 i an imortant intermediary in the downtream ignaling of ecialized antigen recetor, inclding T cell recetor (TCR) and B cell recetor (BCR). A ch, VAV1 ha een imlicated in everal dieae, inclding the atoimmne diorder ytemic l erythemato (SLE) and rhematoid arthriti (RA). In thee condition, anormal VAV1 ignaling can contrite to immne dyreglation and inflammation. Additionally, VAV1 i involved in certain tye of cancer, where aerrant activation can romote celllar tranformation and metatai.-PEGSK(Additional S&H Or Hazmat Fees May Apply)