Revvity PhenoVe HyoxiTRAK, Hyoxia Indicator

Revvity Oxygen molecle ort the intracelllar energy rodction and are ed y everal iochemical rocee. Hyoxia, or low oxygen level, i therefore a ignificant tre that often imair aeroic ecie' aility to rvive and i a key comonent of the athological condition ch a inflammation, cardiovaclar dieae, and cancer. A ch, ndertanding moleclar mechanim nderlying hyoxia indcing condition i crcial. For examle, low oxygen level relt in the reglation of Hyoxia indcile factor (HIF) which in trn reglate the exreion of gene involved in cell rvival, angiogenei, glycolyi, and invaionmetatai.PhenoVe HyoxiTRAK i a far-red florecent molecle that readily enter live cell. It ectral characteritic are hared with DRAQ5.HyoxiTRAK i converted to a metaolite, nder hyoxic condition, which erit in cell for everal day allowing a imle determination of the extent of hyoxia, withot antiody taining. It i non-toxic and ited to contino exore that allow the generation of hyoxia deendent change in cell iology. The HyoxiTRAK-metaolite i deigned to halt cell cycle rogreion, reerving the aolte nmer of hyoxia-exeriencing cell. Cell enitive to cycle arret indced y the HyoxiTRAK-metaolite may ndergo cell death. The non-viale cell fraction i a imle rrogate readot of the hyoxia exerience of cell.Featre:lliNmer of Vial Per Unit: 1liliQantity or Volme Per Vial: 500 µL (10 µM - 5 nmole)liliForm: LiqidliliStorage: 2-8 °C (Do not freeze)liliRecommended Working Concentration: 50 nMliliMaximm Excitation Wavelength: 646 nmliliMaximm Emiion Wavelength: 697 nmliliCommon Filter Set: Cy5liliLive Cell Staining: YeliliFixed Cell Staining: NolilEqivalent Nmer of Microlate:lli3-10 x 96-well microlatelili3-10 x 384-well microlatelili5-16 x 1536-well microlatelil-PEGSK(Additional S&H Or Hazmat Fees May Apply)