Cayman Ganglioside GM1 Asialo Polyclonal Antibody

Ganglioside g_M1 asialo (Item No. ) is a component of cellular lipid rafts and can be formed by the cleavage of the sialic acid residue from ganglioside g_M1 (Item No. ) by neuraminidase.^, Ganglioside g_M1 asialo is a glycolipid receptor for P. aeruginosa flagellin and stimulates defensive responses in host cells, including extracellular ATP release, calcium mobilization, and ERK1/2 phosphorylation when stimulated by flagellin and an anti-ganglioside g_M1 asialo antibody. The percentage of ganglioside g_M1 asialo-positive natural killer (NK) and CD8⁺ T cells in the lung is increased in a mouse model of respiratory syncytial virus (RSV) infection compared with healthy animals. Depletion of ganglioside g_M1 asialo-positive NK and T cells reduces IFN-γ levels in the lung, reduces weight loss, and increases lung viral load in RSV-infected mice. Ganglioside g_M1 Asialo Polyclonal Antibody can be used for ELISA and TLC immunoblotting. [Matreya, LLC. Catalog No. 1950]

WARNING This product is not for human or veterinary use.