Cayman Ganglioside GD3 Monoclonal Antibody

Ganglioside g_D3 (Item No. 17481) is synthesized by the addition of two sialic acid residues to lactosylceramide and can serve as a precursor to the formation of more complex gangliosides by the action of glycosyl- and sialyltransferases. It induces apoptosis in HuT-78 cutaneous T cell lymphoma cells in a concentration-dependent manner and disrupts the mitochondrial membrane potential when used at a concentration of 200 μM. Expression of ganglioside g_D3 in g_D3-negative SK-MEL-28-N1 malignant melanoma cells increases both cell proliferation and invasion in vitro. Ganglioside g_D3-deficient adult mice exhibit progressive loss of the neural stem cell (NSC) pool and impaired neurogenesis. Ganglioside g_D3 Monoclonal Antibody can be used for ELISA and TLC immunobloting. [Matreya, LLC. Catalog No. 1977]

WARNING This product is not for human or veterinary use.