Cell Signaling Src (36d10) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Src (36d10) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-10242SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Src (36d10) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-10242SF

MFG.PART: 10242SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µg
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	60
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #2109
Specificity/Sensitivity	Src (36D10) RmAb (BSA and Azide Free) detects endogenous levels of Src proteins. This antibody cross-reacts with over-expressed levels of Yes and Fyn but does not cross-react with other Src family members.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human Src.
Background	The Src family of protein tyrosine kinases, which includes Src, Lyn, Fyn, Yes, Lck, Blk, and Hck, are important in the regulation of growth and differentiation of eukaryotic cells (1). Src activity is regulated by tyrosine phosphorylation at two sites, but with opposing effects. While phosphorylation at Tyr416 in the activation loop of the kinase domain upregulates enzyme activity, phosphorylation at Tyr527 in the carboxy-terminal tail by Csk renders the enzyme less active (2).