Cell Signaling Il-8 (E5f5q) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Il-8 (E5f5q) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-10681SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Il-8 (E5f5q) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-10681SF

MFG.PART: 10681SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	11
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #94407.
Specificity/Sensitivity	IL-8 (E5F5Q) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total IL-8 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with human IL-8 recombinant protein.
Background	The prototypical CXC chemokine, IL-8, is best known for effects on neutrophils, specifically its ability to act as a chemoattractant and activate degranulation and respiratory burst (1-3).IL-8 is produced by a number of cell types, including monocytes, T cells, neutrophils, fibroblasts, endothelial cells, and others (1). In addition to its effects on neutrophils, IL-8 promotes angiogenesis, inhibits endothelial cell apoptosis, and promotes the proliferation of melanoma cells in an autocrine fashion (1). As a result, IL-8 may be a contributing factor to the development of certain cancers (1,2). There are two distinct receptors for IL-8, CXCR1 and CXCR2; both are g protein-coupled receptors (1). Ligand binding induces Ca2+ mobilization and activates the PI3K, PKC, Rho, and Rac pathways (1,3).

Specifications