We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cell Signaling Upa (E2m6i) Rabbit mAb
List Price $354.51 Your Price $354.51
Cell Signaling Upa (E2m6i) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART: CSIG-15800S
MFG.PART: 15800S
UNSPSC: 12352203
Manufacturer: Cell Signaling
| Size | 100 µl |
| Reactivity | H |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 32, 50 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000} |
| Storage | Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | uPA (E2M6I) Rabbit mAb recognizes endogenous levels of total uPA protein. The antibody detects the 50 kDa zymogen and the 32 kDa chain B, and does not detect chain A. |
| Species Reactivity | Human |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser266 of human uPA protein. |
| Background | uPA (PLAU, urokinase-type plasminogen activator) is a secreted serine protease that plays an important role in plasminogen activation (1). uPA exists as a secreted 50 kDa inactive zymogen. Upon binding to its high affinity serine protease urokinase-type plasminogen activator receptor (uPAR), it is processed to two interlinked chains, 18 kDa chain A and 32 kDa chain B, and becomes activated to convert plasminogen to its active form, plasmin, in a spatially restricted manner on the cell surface (2). Plasmin then carries out its protease activity toward a wide range of substrates. uPA activity is inhibited by serpins (serine protease inhibitors), such as plasminogen activator inhibitor (PAI) (3). uPA, uPAR, and PAI form a Urokinase Plasminogen Activation System (uPAS) (4). This system plays a key role in regulating a broad range of biological processes under normal physiological conditions, such as tissue wound healing (5), cell migration (6), fibrinolysis (7), and angiogenesis (8). The system also contributes to disease progression, such as cancer development (9), neurodegeneration disorders (10), inflammatory lung disease, and rheumatoid arthritis (11,12). |
| SKU | CSIG-15800S |
|---|---|
| Supplier Part Number | 15800S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |