Cell Signaling Etv5 (E5g9v) Rabbit mAb

Name: Cell Signaling Etv5 (E5g9v) Rabbit mAb
SKU: CSIG-16274S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Etv5 (E5g9v) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-16274S

MFG.PART: 16274S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	68
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ETV5 (E5G9V) Rabbit mAb recognizes endogenous levels of total ETV5 protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a recombinant protein fragment specific to human ETV5 protein.
Background	ETV5 (ERM) is a member of the PEA3 (polyomavirus enhancer activator 3) subfamily of the E26 transformation-specific (ETS) DNA-binding transcription factors (1,2). PEA3 subfamily members are considered as oncogenic transcriptional factors due to their close association with and contribution to cancer development. The subfamily of ETS proteins consists of three members: ETV1, ETV4, and ETV5. RAS/MAPK and PKA are identified to be the upstream activator of ETV5 by phosphorylation of the target at serine residues (3-5). In addition to cancer promoting effect, ETV5 also regulates many basic cellular functions during normal development, including embryonic stem cell differentiation (6,7), neuronal cell growth, differentiation, and neuron-dendrite network establishment (8,9), reproduction organ development (10,11), as well as cellular fatty acid metabolism and obesity (12,13).

Specifications