Cell Signaling Mt-Atp8 Antibody

Name: Cell Signaling Mt-Atp8 Antibody
SKU: CSIG-17412S
Price: 418.14 USD

List Price $418.14 Your Price $418.14

Cell Signaling Mt-Atp8 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-17412S

MFG.PART: 17412S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	9
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MT-ATP8 Antibody recognizes endogenous levels of total MT-ATP8 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human MT-ATP8 protein. Antibodies are purified by peptide affinity chromatography.
Background	Mitochondrially-encoded ATP Synthase Membrane Subunit 8 (MT-ATP8) is a product of MT-ATP8, one of 13 protein-encoding genes in the human mitochondrial genome (1). MT-ATP8 comprises one subunit (ATP synthase FO subunit 8) of mitochondrial ATP synthase (Complex V), the inner mitochondrial enzyme that catalyzes the final step of oxidative phosphorylation in the electron transport chain (2). Numerous mutations in MT-ATP8 have been identified that have deleterious effects on ATP synthase function, some of which manifest as debilitating neuronal and/or neuromuscular diseases, including epilepsy, schizophrenia, autism, ataxia, and various cardiomyopathies (3), underscoring the importance of healthy mitochondrial function to organismal health.