Cell Signaling G3bp1 Antibody

Name: Cell Signaling G3bp1 Antibody
SKU: CSIG-17798S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling G3bp1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-17798S

MFG.PART: 17798S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	68
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:50 - 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	G3BP1 Antibody recognizes endogenous levels of total G3BP1 protein. This antibody does not cross-react with G3BP2 protein.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val218 of human G3BP1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Ras GTPase-activating protein-binding protein 1, also known as GAP SH3 domain-binding protein 1 (G3BP1), was identified as a protein that interacts with the SH3 domain of Ras GTPase-activating protein (RasGap) (1). G3BP1 is involved in the regulation of multiple cellular processes, including mRNA decay and inhibition of translation initiation (2). Furthermore, G3BP1 is essential for the assembly of stress granules (SGs) and functions as an SG-nucleating protein (3). Research studies show that arginine demethylation of G3BP1 promotes SG assembly during oxidative stress (4).