Cell Signaling Irg1 Antibody

Name: Cell Signaling Irg1 Antibody
SKU: CSIG-17805S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Irg1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-17805S

MFG.PART: 17805S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	IRG1 Antibody recognizes endogenous levels of total IRG1 protein.
Species Reactivity	Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of mouse IRG1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	IRG1 (Immune-responsive gene 1) is one of the most up-regulated genes in macrophages under proinflammatory conditions (1). It is also highly expressed in the pregnant uterus during implantation (2,3). IRG1 is a cis-aconitate decarboxylase that produces itaconic acid by decarboxylating cis-aconitic acid, an intermediate of the tricarboxylic acid cycle (4). Itaconic acid is an endogenous inhibitor of succinate dehydrogenase, linking macrophage metabolic rewiring and regulation of inflammation (5,6).