Cell Signaling Icos (E5f7e) Rabbit mAb (BSA And Azide Free)

Name: Cell Signaling Icos (E5f7e) Rabbit mAb (BSA And Azide Free)
SKU: CSIG-18670SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Icos (E5f7e) Rabbit mAb (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-18670SF

MFG.PART: 18670SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	22-35
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #67223
Specificity/Sensitivity	ICOS (E5F7E) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total mouse ICOS protein.
Species Reactivity	Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val198 of mouse ICOS protein.
Background	ICOS (Inducible Co-Stimulator, CD278) is a member of the CD28 family that regulates T cell activity and immune responses (1). The ICOS protein contains an extracellular IgV-like domain, a transmembrane domain, and an intracellular domain with a YMFM motif (1-2). ICOS is primarily expressed on activated CD4+ and CD8+ T cells (1). Upon binding to its ligand, ICOS potentiates the T cell response to antigen through activation of the PI3K signaling pathway (3). In addition to enhancing T cell activation and proliferation, ICOS plays an important role in the regulation of T follicular helper cells (4). Research studies suggest that ICOS is a potential therapeutic target, and could serve as a prognostic biomarker for neoplastic therapy involving CTLA-4 blockade (5-7).

Specifications