Cell Signaling Aldh2 Antibody

Name: Cell Signaling Aldh2 Antibody
SKU: CSIG-18818S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Aldh2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-18818S

MFG.PART: 18818S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	56
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	ALDH2 Antibody recognizes endogenous levels of total ALDH2 protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val348 of human ALDH2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Aldehyde dehydrogenase 2 (ALDH2) is a member of the aldehyde dehydrogenase superfamily (1). The enzymes in this family catalyze the oxidation of a variety of aldehydes, leading to their detoxification (1, 2). ALDH2 activation correlates with decreased ischemic heart injury, suggesting an essential role of ALDH2 in cardiac protection from ischemic injury (3). In addition, ALDH2 is the primary enzyme for aldehyde oxidation in hematopoietic stem cells (4). ALDH2 is required for protecting these cells from DNA damage caused by acetaldehyde and has a critical function to counteract genotoxicity (4, 5).