Cell Signaling Gatad2a Antibody

Name: Cell Signaling Gatad2a Antibody
SKU: CSIG-19388S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Gatad2a Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-19388S

MFG.PART: 19388S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	70, 73
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	GATAD2A Antibody recognizes endogenous levels of total GATAD2A protein. This antibody does not cross-react with GATAD2B protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro56 of human GATAD2A protein. Antibodies are purified by peptide affinity chromatography.
Background	GATAD2A and GATAD2B, also known as p66 alpha and p66 beta, are related members of the nucleosome remodeling and deacetylase (NuRD) complex (1). GATAD2A interacts with MBD2 to recruit the deacetylase core of the NuRD complex to repress target genes, a process that is enhanced by the sumoylation of GATAD2A at Lys30 and Lys487 (2-5). In addition to being sumoylated, GATAD2A has also been shown to be phosphorylated by AMPK in the memory formation process (6). Depletion of GATAD2A in order to reduce NuRD-dependent repression of key pluripotency genes is being explored in the context of induced pluripotent stem cell (iPSC) generation (7,8).