Cell Signaling Cdca5 (E7m3n) Rabbit mAb

Name: Cell Signaling Cdca5 (E7m3n) Rabbit mAb
SKU: CSIG-20180S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Cdca5 (E7m3n) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-20180S

MFG.PART: 20180S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	35
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:100}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CDCA5 (E7M3N) Rabbit mAb recognizes endogenous levels of total CDCA5 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Phe247 of human CDCA5 protein.
Background	Cohesin is a ring-shaped multiprotein complex that functions in sister chromatid cohesion and in establishing higher order chromosome structure. The cohesin complex regulates chromosome segregation, DNA repair, and transcription (1,2).CDCA5 (also known as Sororin) stabilizes the cohesin complex on DNA through inhibition of the cohesion antagonist WAPL (3). CDCA5 promotes cell proliferation and inhibits apoptosis through the AKT signaling pathway in hepatocellular carcinoma (HCC) cells (4). Overexpression of CDCA5 indicates poor prognosis in HCC (5-7).