Cell Signaling Miwi (D478) Antibody

Name: Cell Signaling Miwi (D478) Antibody
SKU: CSIG-2025S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Miwi (D478) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2025S

MFG.PART: 2025S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	90
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Miwi (D478) Antibody detects endogenous levels of total Miwi protein.
Species Reactivity	Human, Mouse
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp478 of mouse Miwi. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The Drosophila piwi gene was identified as being required for the self-renewal of germline stem cells (1). Piwi homologs are well conserved among various species including Arabidopsis, C. elegans, and Homo sapiens (1). Both Miwi and Mili proteins are mouse homologs of Piwi and contain a C-terminal Piwi domain (2). Miwi and Mili bind to Piwi-interacting RNAs (piRNAs) in male germ cells and are essential for spermatogenesis in mice (3-5).

Specifications