Cell Signaling Tmp21 Antibody

Name: Cell Signaling Tmp21 Antibody
SKU: CSIG-2076S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Tmp21 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2076S

MFG.PART: 2076S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	19
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TMP21 Antibody detects endogenous levels of total TMP21 protein.
Species Reactivity	Human, Mouse, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues of human TMP21. Antibodies are purified by protein A and peptide affinity chromatography.
Background	TMP21, a type I transmembrane protein, is a member of the p24 cargo protein family, which is highly enriched in the ER, the Golgi and coat protein (COP) I and II transport vesicles (1,2). TMP21 is involved in protein transport and vesicular targeting. In particular, TMP21 influences APP trafficking by stabilizing nascent APP. The absence of TMP21 leads to enhanced maturation and cell surface accumulation of APP (3). In addition, TMP21 is a non-essential component of the γ-secretase complex with the potential to modulate γ-secretase mediated cleavage and Aβ production without having an effect on ε-secretase activity (4).

Specifications