Cell Signaling La Antigen Antibody

Name: Cell Signaling La Antigen Antibody
SKU: CSIG-2081S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling La Antigen Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2081S

MFG.PART: 2081S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	50
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	La Antigen Antibody detects endogenous levels of total La Antigen protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human La Antigen. Antibodies are purified by protein A and peptide affinity chromatography.
Background	La antigen is recognized by antibodies in patients with autoimmune disorders such as systemic lupus erythematosus and Sjögrens syndrome (1). La antigen binds to the 5-noncoding region of poliovirus RNA and is an IRES trans-acting factor (1,2). Depletion of La antigen reduces the function of poliovirus IRES in vivo (3). La antigen, when phosphorylated at Ser366, has been shown to associate with nuclear precursor tRNAs and facilitate their processing (4). The nonphosphorylated La antigen interacts with the mRNAs that have 5-terminal oligopyrimidine (5TOP) motifs to control protein synthesis (4).

Specifications