Cell Signaling Cdk7 Antibody

Name: Cell Signaling Cdk7 Antibody
SKU: CSIG-2090S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Cdk7 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2090S

MFG.PART: 2090S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	40
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CDK7 Antibody detects endogenous levels of total CDK7 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human CDK7. Antibodies are purified using protein A and peptide affinity chromatography.
Background	CDK-activating kinase (CAK) is a complex of CDK7 and cyclin H. The complex is involved in cell cycle regulation by phosphorylating an activating residue in the T-loop domain of cdks (1). Regulation of CAK activity is mediated by T-loop phosphorylation and by association with MAT1, both of which enhance its kinase activity toward the CTD of RNA polymerase II (2,3) and other substrates such as p53 (4). CAK is an essential component of the transcription complex TFIIH and may interact directly with TFIIH helicases (5).

Specifications