Cell Signaling 4e-T Antibody

Name: Cell Signaling 4e-T Antibody
SKU: CSIG-2297S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling 4e-T Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-2297S

MFG.PART: 2297S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	140
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	4E-T Antibody detects endogenous levels of total 4E-T protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human 4E-T. Antibodies are purified by protein A and peptide affinity chromatography.
Background	During translation, eIF4E binds to the 5 cap structure of mRNA and helps mRNA bind to the ribosome. There are several factors that associate with eIF4E. One of these factors is eIF4E-Transporter (4E-T) (1). 4E-T has an eIF4E binding site, a nuclear localization signal and two nuclear export signals (1). Studies demonstrate that 4E-T functions as a nucleocytoplasmic shuttling protein mediating the import of eIF4E into the nucleus (1). Recent findings indicate that 4E-T, along with eIF4E, is concentrated in the processing bodies (P-bodies) in the cytoplasm (2). Furthermore, 4E-T decreases mRNA stability (2).

Specifications